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KMID : 0613820180280091092
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Journal of Life Science
2018 Volume.28 No. 9 p.1092 ~ p.1099
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Anti-oxidative Activity of Five Plant Extracts including Apios fortune, Colubrina arborescens, Croton caudatus, Osmanthus matsumuranus and Schima noronhae
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Lee Su-Hyeon
Jin Kyong-Suk
Kwon Hyun-Ju
Kim Byung-Woo
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Abstract
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This study was orchestrated with the purpose of uncovering new nutraceutical resources possessing biological activities in the plant kingdom. To fulfill our objective, we analyzed several plant extracts and selected five species possessing powerful anti-oxidative activity. The anti-oxidative effect of these five plants, Apios fortunei Maxim., Colubrina arborescens Sarg., Croton caudatus Geiseler, Osmanthus matsumuranus Hayata and Schima noronhae Reinw. ethanol extracts were then evaluated by using in vitro assay, cell model system, and Western blot analysis of target proteins. As the results, all of them possessed the potent scavenging activity against 1,1-diphenyl-2-picryl hydrazyl (DPPH), similar with that of ascorbic acid, used as a common positive control. Moreover, they strongly inhibited hydrogen peroxide (H2O2)-induced reactive oxygen species (ROS), in a dose-dependent manner, in RAW 264.7 murine macrophage cells. Furthermore, they induced the protein expression of an anti-oxidative enzyme, heme oxygenase 1 (HO-1), and its upstream transcription factor, nuclear factor-E2-related factor 2 (Nrf2). Taken together, these results indicate that these five plants possess potent anti-oxidative activity and thus appear to be useful sources as potential anti-oxidant agents. Therefore, they might be utilized as promising materials in the field of nutraceuticals.
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KEYWORD
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Anti-oxidative activity, five plants extracts, heme oxygenase 1, nuclear factor-E2-related factor 2
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